Treatment-resistant depression happens if you have taken 2 or more oral antidepressants and still experience symptoms of depression.
FDA-approved, Covered by Insurance
Get Rapid Relief with Spravato®
When antidepressants haven't worked, Spravato® may offer a different path. Find out if you're a candidate, or keep reading to learn more.
Spravato® is the only FDA-approved nasal spray for treatment-resistant depression.
Spravato® is an FDA-approved nasal spray for adults living with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts. Administered under clinical supervision, it works through a different mechanism than standard antidepressants, and it's the only ketamine-based therapy covered by most major insurance plans.
Easy access
Covered by insurance
Delivered at in-person clinics
What conditions can Spravato® treat?
Spravato® is specifically designed as a standalone treatment or alongside an oral antidepressant for adults who haven't found relief with traditional antidepressants.
Treatment-Resistant Depression (TRD)
Major Depressive Disorder with Suicidal Ideation (MDSI)
Severe clinical depression with recurring suicidal thoughts or actions.
Spravato® shows significant improvement in depression symptoms within 24 hours — and continues to demonstrate rapid improvement in symptoms at 4 weeks.
What does the Spravato® treatment process look like?
01
60 mins - telehealth
Consultation
Evaluation with one of our prescribers where they will determine eligibility.
02
Weeks 1-4
Induction
Two times a week in an in-person clinic.
03
Weeks 5-8
Optimization
Once a week in an in-person clinic.
04
Ongoing
Maintenance
Once a week or every 2 weeks based on your individual needs.
Every session is administered and monitored by a Spravato®-trained clinician for your safety.
The Spravato®withMe program offers rebates to help cover eligible out-of-pocket costs. Based on your insurance benefits and deductible, eligible patients can receive assistance that reduces treatment expenses to as low as $10 per session.
As low as $10 a session with insurance.
Experience Spravato® in a Setting Built for Comfort
Spravato® sessions at Journey Clinical take place in a therapist's private office — not a large clinic or hospital setting. You'll be treated alongside a few other patients, in a calm, quiet environment designed to support your experience rather than distract from it.
Real Stories from Spravato® Patients
It's really like a veil had lifted [after Spravato]. I am in a better place now than I have been maybe ever. And I think that's an amazing gift.
Grace, CO
Some days I would just collapse in a fit of crying, on only 5 hours of sleep a week. With Spravato®, I was learning to love myself each and every session — and I'm really proud of where I am now.
Ben, NY
My symptoms were so severe I was laid off and couldn't socialize. Spravato® gave me hope — not just to get through the day, but to start over.
Karen, IL
I would sleep 18 to 20 hours a day and I truly hated myself. After starting Spravato®, I'm waking up neutral every day — and for me, that's everything.
Nicole, MO
Take the first step today.
Find a Journey Clinical Spravato® center near you and fill out the brief form on the center's profile to begin your path to relief.
Don't see your city?
Join our waitlist to be notified when a Spravato® center opens near you.